Metabolism of trichloroethylene and tetrachloroethylene in human subjects.
نویسنده
چکیده
A linear correlation exists between the trichloroethylene concentration in the work environments and the level of total trichloro compounds in the urine of the workers, as expressed by the equation: Gamma = 7.25=chi + 5.5, where Gamma is trichloroethylene in air (ppm) is Chi is total trichloro compounds in urine (mg/l). Trichloroethanol level is also linearly related to trichloroethylene concentration, while trichloroacetic acid level deviates from the linear relation when trichloroethylene level exceeds 50 ppm. In the case of tetrachloroethylene exposure, both trichloroethanol and trichloroacetic acid levels, and consequently the total trichloro compound level, reach a plateau at tetrachloroethylene level well below 100 ppm. The mean urinary biological half-life is 41 hr for trichloroethylene and 144 hr for tetrachloroethylene. The two values are the largest of the values so far obtained with organic solvents. The respiratory half-life is shorter than the urinary half-life, both in richloroethylene and in tetrachloroethylene. Applications of the urinalyses in clinical cases are described. In one case of trichlorethylene dependency, a longer urinary half-life of 73 hr was observed. An automated system is presented for the determination of total trichloro compounds in human urine. The system can analyze the samples at the rate of 20 samples per hour with an accuracy comparable to that of the time-consuming manual analysis.
منابع مشابه
Metabolism of halogenated ethylenes.
The metabolism of the chlorinated ethylenes may be explained by the formation of chloroethylene epoxides as the first intermediate products. The evidence indicates that these epoxides rearrange with migration of chlorine to form chloroacetaldehydes and chloroacetyl chlorides. Thus, monochloroacetic acid, chloral hydrate, and trichloroacetic acid have been found in reaction mixtures of 1,1-dichl...
متن کاملUrinary excretion of total trichloro-compounds, trichloroethanol, and trichloroacetic acid as a measure of exposure to trichloroethylene and tetrachloroethylene.
Ikeda, M., Ohtsuji, H., Imamura, T., and Komoike, Y. (1972). Brit. J. industr. Med., 29, 328-333. Urinary excretion of total trichloro-compounds, trichloroethanol, and trichloroacetic acid as a measure of exposure to trichloroethylene and tetrachloroethylene. To investigate the relation between trichloroethylene and tetrachloroethylene concentrations in working environments and metabolite conce...
متن کاملExcretion of organic chlorine compounds in the urine of persons exposed to vapours of trichloroethylene and tetrachloroethylene.
Ogata, M., Yoshiko, T., and Tomokuni, K. (1971). Brit. J. industr. Med., 28, 386-391. Excretion of organic chlorine compounds in the urine of persons exposed to vapours of trichloroethylene and tetrachloroethylene. Male volunteers were exposed to 170 p.p.m. of trichloroethylene vapour either for 3 hours or for 7 hours with one break of 1 hour; or to 87 p.p.m. of tetrachloroethylene vapour for 3...
متن کاملRole of methanogenic and sulfate-reducing bacteria in the reductive dechlorination of tetrachloroethylene in mixed culture.
Several reports have demonstrated biotransformation of tetrachloroethylene at low concentrations under strict anaerobic conditions by sequential reductive dechlorination (Fathepure and Boyd, 1988a; Freedman and Gosset, 1989). During this biodegradation, trichloroethylene (TCE), 1,1dichloroethylene, vinylidene chloride (DCE), and vinyl chloride (VC) are the intermediate products ; ethene or etha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 21 شماره
صفحات -
تاریخ انتشار 1977